After his studies at the Accademia delle Belle Arti in Rome, Prampolini was in contact with members of various avant-garde artists from Picasso to Jean Cocteau, Mondrian to Kandinsky. Although one of the most prominent figures in Futurism, he was also close to other groups such as Dada and Section d’Or, Cercle et Carré, Abraction-Création, Bauhaus and De Stijl, working as an artist and architect at the same time. He collaborated with the magazine Varietas and founded Noi few years later. Still very young he created stage design for Thaïs and Perfido incanto Futurist movies. He founded the Casa d’Arte Italiana and the Teatro della Pantomima Futurista, for which he continued to work on set design. He also set out the international exhibition in San Francisco and New York, creating decorative panelling on some of the rooms and dedicated himself to the exploration of polimaterismo.